Publications

(Since 2000)

2000

Stanton, M.E. & Freeman, J.H., Jr. (2000). Developmental studies of eyeblink conditioning in a rat model. In D.S. Woodruff-Pak and J.E. Steinmetz (Eds.) Eyeblink Classical Conditioning: Animal. Amsterdam: Kluwer.

Freeman, J.H., Jr. & Nicholson, D.A. (2000). Developmental changes in eye-blink conditioning and neuronal activity in the cerebellar interpositus nucleus. The Journal of Neuroscience, 20, 813-819.

Nicholson, D.A. & Freeman, J.H., Jr. (2000). Lesions of the perirhinal cortex impair sensory preconditioning in rats. Behavioural Brain Research, 112, 69-75.

Nicholson, D.A. & Freeman, J.H., Jr. (2000). Developmental changes in eye-blink conditioning and neuronal activity in the inferior olive. The Journal of Neuroscience, 20, 8218-8226.

 

2001

Freeman, J.H., Jr. & Nicholson, D.A. (2001). Ontogenetic changes in the neural mechanisms of eyeblink conditioning. Integrative Physiological and Behavioral Science, 36, 15-35.

Smith, D.M., Monteverde, J., Schwartz, E., Freeman, J.H., Jr., & Gabriel, M. (2001). Lesions in the central nucleus of the amygdala: effects on discriminative avoidance learning, discriminative approach learning and cingulothalamic training-induced neuronal activity. Neurobiology of Learning & Memory, 76, 403-425.

 

2002

Nicholson, D.A. & Freeman, J.H., Jr. (2002). Neuronal correlates of conditioned inhibition of the eyeblink response in the anterior interpositus nucleus. Behavioral Neuroscience, 116, 22-36.

Nicholson, D.A. & Freeman, J.H., Jr. (2002). Medial dorsal thalamic lesions impair latent inhibition and blocking of the conditioned eyeblink response in rats. Behavioral Neuroscience, 116, 276-285.

Wemmie, J.A., Chen, J., Askwith, C.C., Hruska-Hageman, A.M., Price, M.P., Nolan, B.C., Yoder, P.G., Lamani, E., Hoshi, T., Freeman, J.H., Jr., & Welsh, M.J. (2002). The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron, 34, 463-477. 

Smith, D.M., Freeman, J.H., Jr., Nicholson, D.A., & Gabriel, M. (2002). Limbic thalamic lesions, appetitively motivated discrimination learning, and training-induced neuronal activity in rabbits. Journal of Neuroscience, 22, 8212-8221.

Kleim, J.A.*, Freeman, J.H., Jr.*, Bruneau, R., Nolan, B.C., Cooper, N.R., Zook, A., & Walters, D. (2002). Synapse formation is associated with memory storage in the cerebellum. Proceedings of the National Academy of Sciences (USA), 99, 13228-13231.

Nolan, B.C., Nicholson, D.A., & Freeman, J.H., Jr. (2002). Blockade of GABAA receptors in the interpositus nucleus modulates expression of conditioned excitation but not conditioned inhibition of the eyeblink response. Integrative Physiological & Behavioral Science, 37, 293-310.

 

2003

Freeman, J.H., Jr., Nicholson, D.A., Muckler, A., Rabinak, C., & DiPietro, N. (2003). Ontogeny of eyeblink conditioned response timing in rats.Behavioral Neuroscience, 117, 283-291.

Nicholson, D.A, & Freeman, J.H., Jr. (2003). Addition of inhibition in the olivocerebellar system and the ontogeny of a motor memory. Nature Neuroscience, 6, 532-537.

Wemmie, J.A., Askwith, C.C., Lamani, E., Cassell, M.D., Freeman, J.H., Jr., & Welsh, M.J. (2003). Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. Journal of Neuroscience, 23, 5496-5502.

Nicholson, D.A., Sweet, J.A., & Freeman, J.H., Jr. (2003). Long-term retention of the classically conditioned eyeblink response in rats. Behavioral Neuroscience, 117, 871-875.

Nicholson, D.A., & Freeman, J.H., Jr. (2003). Developmental changes in evoked Purkinje cell complex spike responses. Journal of Neurophysiology, 90, 2349-2357.

Freeman, J.H., Jr, & Muckler, A.S. (2003). Developmental changes in eyeblink conditioning and neuronal activity in the pontine nuclei. Learning & Memory, 10, 337-345.

 

2004

Nicholson, D.A., & Freeman, J.H., Jr. (2004). Developmental changes in eyeblink conditioning and simple spike activity in the cerebellar cortex.Developmental Psychobiology, 44, 45-57.

Freeman, J.H., Jr., & Nicholson, D.A. (2004). Developmental changes in the neural mechanisms of eyeblink conditioning. Behavioral and Cognitive Neuroscience Reviews, 3, 3-13.

Nicholson, D.A., & Freeman, J.H., Jr. (2004). Selective developmental increase in the climbing fiber input to the cerebellar interpositus nucleus in rats. Behavioral Neuroscience, 118, 1111-1116.

Lim, R., Zaheer, A., Khosravi, H., Freeman, J.H., Jr., Halverson, H.E., Wemmie, J.A., &Yang, B. (2004). Impaired motor performance and learning in glia maturation factor-knockout mice. Brain Research, 1024, 225-232.

Freeman, J.H., Jr., & Rabinak, C.A. (2004). Eyeblink conditioning in rats using pontine stimulation as a conditioned stimulus. Integrative Physiological & Behavioral Science39, 180-191.

 

2005

Nolan, B.C., & Freeman, J.H., Jr. (2005). Purkinje cell loss by OX7-saporin impairs excitatory and inhibitory eyeblink conditioning. Behavioral Neuroscience, 119, 190-201.

Freeman, J.H., Jr., Halverson, H.E., & Poremba, A. (2005). Differential effects of cerebellar inactivation on eyeblink conditioned excitation and inhibition. Journal of Neuroscience, 25, 889-895.

Freeman, J.H., Jr., Rabinak, C.A., & Campolattaro, M. (2005). Pontine stimulation overcomes developmental limitations in the neural mechanisms of eyeblink conditioning. Learning & Memory, 12, 255-259.

 

2006

Campolattaro, M.M., & Freeman, J.H. (2006). Perirhinal cortex lesions impair feature-negative discrimination. Neurobiology of Learning and Memory, 86, 205-213.

Halverson, H.E., & Freeman, J.H. (2006). Medial auditory thalamic nuclei are necessary for eyeblink conditioning. Behavioral Neuroscience, 120, 880-887.

Campolattaro, M.M., & Freeman, J.H. (2006). Perirhinal cortex lesions impair feature-positive discrimination. Behavioral Neuroscience, 120, 970-975.

Nolan, B.C., & Freeman, J.H. (2006). Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning. Learning & Memory, 13, 359-365.

 

2007

Plakke, B., Freeman, J.H., & Poremba, A. (2007). Metabolic mapping of the rat cerebellum during delay and trace eyeblink conditioning.Neurobiology of Learning and Memory, 88, 11-18.

Campolattaro, M.M., Halverson, H.E., & Freeman, J.H. (2007). Medial auditory thalamic stimulation as a conditioned stimulus for eyeblink conditioning in rats. Learning & Memory, 14, 152-159.

Freeman, J.H., Halverson, H.E., & Hubbard, E.M. (2007). Inferior colliculus lesions impair eyeblink conditioning in rats. Learning & Memory, 14, 842-846.

Hunt, P.S., Fanselow, M.S., Richardson, R., Mauk, M.D., Freeman, J.H., and Stanton, M.E. (2007). Synapses, Circuits and the Ontogeny of Learning.Developmental Psychobiology, 49, 649-663.

 

2008

Campolattaro, M.M., Schnitker, K.M., & Freeman, J.H. (2008). Changes in inhibition during differential eyeblink conditioning with increased training. Learning & Behavior, 36, 158-164.

Freeman, J.H., & Campolattaro, M.M. (2008). Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning. Learning & Memory, 15, 823-828.

Freeman, J.H., & Duffel, J. (2008). Eyeblink conditioning using cochlear nucleus stimulation as a conditioned stimulus in developing rats.Developmental Psychobiology, 50, 640-646.

Campolattaro, M.M., & Freeman, J.H. (2008). Eyeblink conditioning in 12-day-old-rats using pontine stimulation as the conditioned stimulus.Proceedings of the National Academy of Sciences (USA), 105, 8120-8123.

Halverson, H.E., Poremba, A., & Freeman, J.H. (2008). Medial auditory thalamus inactivation prevents acquisition and retention of eyeblink conditioning. Learning & Memory, 15, 532-538.

 

2009

Campolattaro, M.M., & Freeman, J.H. (2009). An examination of bilateral eyeblink conditioning in rats. Behavioral Neuroscience, 123, 1346-1352.

Plakke, B., Freeman, J.H., & Poremba, A. (2009). Metabolic mapping of the rat forebrain and midbrain during delay and trace eyeblink conditioning. Neurobiology of Learning and Memory, 92, 335-344.

Campolattaro, M.M., & Freeman, J.H. (2009). Cerebellar inactivation impairs cross modal savings of eyeblink conditioning. Behavioral Neuroscience, 123, 292-302.

Halverson, H.E., Hubbard, E.M., and Freeman, J.H. (2009). Stimulation of the lateral geniculate, superior colliculus, or visual cortex is sufficient for eyeblink conditioning in rats. Learning & Memory, 16, 300-307.

 

2010

Freeman, J.H. (2010). Developmental neurobiology of cerebellar learning. In Blumberg, M.S., Freeman, J.H., & Robinson, S.R. (Eds.). Oxford Handbook of Developmental Behavioral Neuroscience. Oxford University Press.

Steinmetz, A.B., & Freeman, J.H. (2010). Central cannabinoid receptors modulate acquisition of eyeblink conditioning. Learning & Memory, 17, 571-576.

Halverson, H.E., Lee, I., & Freeman, J.H. (2010). Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning. The Journal of Neuroscience, 30, 8787-8796.

Halverson, H.E., & Freeman, J.H. (2010).Ventral lateral geniculate input to the medial pons is necessary for visual eyeblink conditioning in rats.Learning & Memory, 17, 80-85.

Halverson, H.E., Poremba, A. & Freeman, J.H. (2010). Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning. Neurobiology of Learning and Memory, 93, 92-98.

 

2011

Freeman, J.H., and Steinmetz, A.B. (2011). Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning. Learning & Memory, 18, 666–677.

Steinmetz, A.B., & Freeman, J.H. (2011). Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids. Learning & Memory, 18, 634–638.

Campolattaro, M.M., Kashef, A., Lee, I., & Freeman, J.H. (2011). Neuronal correlates of cross-modal transfer in the cerebellum and pontine nuclei.The Journal of Neuroscience, 31, 4051– 4062.

 

2012

Parker, K.L., Andreasen, N.C., Liu, D., Freeman, J.H., Boles Ponto, L.L., & O’Leary, D.S. (2012). Eyeblink conditioning in healthy adults: a positron emission tomography study. Cerebellum, 11, 946-956.

Wasserman, E.A., Castro, L., & Freeman, J.H. (2012). Same-different categorization in rats. Learning & Memory, 19, 142-145.

Ng, K., & Freeman, J.H. (2012). Developmental changes in medial auditory thalamic contributions to associative motor learning. The Journal of Neuroscience, 32, 6841-6850.

 

2013

Parker, K.L., Andreasen, N.C., Liu, D., Freeman, J.H., & O’Leary, D.S. (2013). Eyeblink conditioning in unmedicated schizophrenia patients: A positron emission tomography study. Psychiatry Research, 214, 402-409.

Steinmetz, A.B., Harmon, T.C., & Freeman, J.H. (2013). Visual cortical contributions to associative cerebellar learning. Neurobiology of Learning and Memory, 104, 103-109. 

Steinmetz, A.B., Buss, E.W., & Freeman, J.H. (2013). Inactivation of the ventral lateral geniculate and nucleus of the optic tract impairs retention of visual eyeblink conditioning. Behavioral Neuroscience, 127, 690-693.

Steinmetz, A.B., & Freeman, J.H. (2013). Differential effects of the cannabinoid agonist WIN55,212-2 on delay and trace eyeblink conditioning. Behavioral Neuroscience, 127, 694-702.

Brooks, D.I., Ng, K.H., Buss, E.W., Marshall, A.T., Freeman, J.H., & Wasserman, E.A. (2013). Categorization of photographic images by rats using shape-based image dimensions. Journal of Experimental Psychology: ABP, 39, 85-92.

 

2014

Brown, K.L., & Freeman, J.H. (2014). Extinction, reacquisition, and rapid forgetting of eyeblink conditioning in developing rats. Learning & Memory, 21, 696-708.

Kashef, A., Campolattaro, M.M., & Freeman, J.H. (2014). Learning-related neuronal activity in the ventral lateral geniculate nucleus during associative cerebellar learning. Journal of Neurophysiology, 112, 2234-2250. 

Steinmetz, A.B., & Freeman, J.H. (2014). Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats. Neurobiology of Learning and Memory, 114, 148-154.

Freeman, J.H. (2014). The ontogeny of associative cerebellar learning. International Review of Neurobiology, 117, 53-72.

Goldsberry, M.E., Elkin, M.E., & Freeman, J.H. (2014). Sensory system developmental influences the ontogeny of eyeblink conditioning. Developmental Psychobiology, 56, 1244-1251.

Ng, K., & Freeman, J.H. (2014). Amygdala inactivation impairs eyeblink conditioning in developing rats. Developmental Psychobiology, 56, 999-1007. 

 

2015

Freeman, J.H. (2015). Cerebellar learning mechanisms. Brain Research Special Issue. Brain and Memory: Old Arguments and New Perspectives. Brain Research, 1621, 260-269. 

Halverson, H.E., Poremba, A., & Freeman, J.H. (2015) Medial auditory thalamus is necessary for acquisition and retention of eyeblink conditioning to cochlear nucleus stimulation. Learning & Memory, 22, 258-266.

Goldsberry, M.E., Kim, J., & Freeman, J.H. (2015). Developmental changes in hippocampal associative coding. The Journal of Neuroscience, 35, 4238-4247.

Harmon, T.C., & Freeman, J.H. (2015). Ontogeny of septohippocampal modulation of delay eyeblink conditioning. Developmental Psychobiology, 57, 168-176. 

Campolattaro, M.M., Buss, E.W., & Freeman, J.H. (2015). Cross-modal savings in the contralateral eyelid conditioned response. Behavioral Neuroscience, 129, 683-691.

 

2016

Farley, S.J., Radley, J.J., & Freeman, J.H. (2016). Amygdala modulation of cerebellar learning. The Journal of Neuroscience, 36, 2190 –2201.

Kim, J., Wasserman, E.A., Castro, L., & Freeman, J.H. (2016). Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory. Behavioral Neuroscience, 130, 75-90.

Brown, K.L., & Freeman, J.H. (2016). Retention of eyeblink conditioning in periweanling and adult rats. Developmental Psychobiology, 58, 1055-1065.

Kim, J., Goldsberry, M.E., Harmon, T.C., & Freeman, J.H. (2016). Developmental changes in hippocampal CA1 single neuron firing and theta activity during associative learning. PloS One, 11, 1-22.

Steinmetz, A.B., & Freeman, J.H. (2016). Cannabinoid modulation of memory consolidation within the cerebellum. Neurobiology of Learning and Memory, 136, 228-235.

 

2017

Goldsberry, M.E., & Freeman, J.H. (2017). Sensory system development influences the ontogeny of trace eyeblink conditioning. Developmental Psychobiology, 59, 70-76.

Goldsberry, M.E., Kim, J., & Freeman, J.H. (2017). Sensory system development influences the ontogeny of hippocampal associative coding and trace eyeblink conditioning. Neurobiology of Learning and Memory, 143, 67-76.

Steinmetz, A.B., Ng, K.H., & Freeman, J.H. (2017). Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning. Learning & Memory, 24, 225-230.

 

2018

Kim, J., Castro, L., Wasserman, E.A., & Freeman, J.H. (2018). Dorsal hippocampus is necessary for visual categorization in rats. Hippocampus, 28, 392-405.

Farley, S.J., Albazboz, H., De Corte, B.J., Radley, J.J., & Freeman, J.H. (2018). Amygdala central nucleus modulation of cerebellar learning with a visual conditioned stimulus. Neurobiology of Learning and Memory, 150, 84-92.

Steinmetz, A.B., & Freeman, J.H. (2018). Cannabinoid agonist administration within the cerebellar cortex impairs motor learning. Neurobiology of Learning and Memory,S1074-7427(18)30151-5.

Wahlstrom, K.L., Huff, M.L., Emmons, E.B., Freeman, J.H., Narayanan, N.S., McIntyre, C.K., & LaLumiere, R.T. (2018). Basolateral amygdala inputs to the medial entorhinal cortex selectively modulate the consolidation of spatial and contextual learning. The Journal of Neuroscience, 38, 2698-2712.

 

2019

Broschard, M.B., Kim, J., Love, B.C., Wasserman, E.A., & Freeman, J.H. (2019). Selective attention in rat visual category learning. Learning & Memory, 26, 84-92.

 

2020

Freeman, J.H., Farley, S.J., & Pierson, S.R. (2020). Amygdala central nucleus modulation of cerebellar learning in female rats. Behavioral Neuroscience, in press.

Broschard, M.B., Kim, J., Love, B.C., & Freeman, J.H. (2020). Category learning in rodents using touchscreen-based tasks. Genes, Brain and Behavior, e12665. doi: 10.1111/gbb.12665.

Steinmetz, A.B., & Freeman, J.H. (2020). Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning. Behavioural Brain Research, 378, 112258. doi: 10.1016/j.bbr.2019.112258.

Steinmetz, A.B., & Freeman, J.H. (2020). Cannabinoid agonist administration within the cerebellar cortex impairs motor learning. Neurobiology of Learning and Memory, 170, 106896. doi: 10.1016/j.nlm.2018.06.015.